Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.
Identifieur interne : 000646 ( Main/Exploration ); précédent : 000645; suivant : 000647Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.
Auteurs : Jennifer G. Wilson ; Laura J. Simpson [États-Unis] ; Anne-Maud Ferreira [États-Unis] ; Arjun Rustagi [États-Unis] ; Jonasel Roque [États-Unis] ; Adijat Asuni [États-Unis] ; Thanmayi Ranganath [États-Unis] ; Philip M. Grant [États-Unis] ; Aruna Subramanian [États-Unis] ; Yael Rosenberg-Hasson [États-Unis] ; Holden T. Maecker [États-Unis] ; Susan P. Holmes [États-Unis] ; Joseph E. Levitt [États-Unis] ; Catherine A. Blish [États-Unis] ; Angela J. Rogers [États-Unis]Source :
- JCI insight [ 2379-3708 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Antagoniste du récepteur à l'interleukine-1 (immunologie), Antagoniste du récepteur à l'interleukine-1 (sang), Cytokines (immunologie), Cytokines (sang), Facteur de nécrose tumorale alpha (immunologie), Facteur de nécrose tumorale alpha (sang), Femelle (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (immunologie), Infections à coronavirus (sang), Interleukine-1 bêta (immunologie), Interleukine-1 bêta (sang), Interleukine-18 (immunologie), Interleukine-18 (sang), Interleukine-6 (immunologie), Interleukine-6 (sang), Interleukine-8 (immunologie), Interleukine-8 (sang), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (immunologie), Pneumopathie virale (sang), Sepsie (immunologie), Sepsie (sang), Sujet âgé (MeSH), Études cas-témoins (MeSH).
- MESH :
- immunologie : Antagoniste du récepteur à l'interleukine-1, Cytokines, Facteur de nécrose tumorale alpha, Infections à coronavirus, Interleukine-1 bêta, Interleukine-18, Interleukine-6, Interleukine-8, Pneumopathie virale, Sepsie.
- sang : Antagoniste du récepteur à l'interleukine-1, Cytokines, Facteur de nécrose tumorale alpha, Infections à coronavirus, Interleukine-1 bêta, Interleukine-18, Interleukine-6, Interleukine-8, Pneumopathie virale, Sepsie.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité de la maladie, Mâle, Pandémies, Sujet âgé, Études cas-témoins.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), COVID-19 (MeSH), Case-Control Studies (MeSH), Coronavirus Infections (blood), Coronavirus Infections (immunology), Cytokine Release Syndrome (blood), Cytokine Release Syndrome (immunology), Cytokines (blood), Cytokines (immunology), Female (MeSH), Humans (MeSH), Interleukin 1 Receptor Antagonist Protein (blood), Interleukin 1 Receptor Antagonist Protein (immunology), Interleukin-18 (blood), Interleukin-18 (immunology), Interleukin-1beta (blood), Interleukin-1beta (immunology), Interleukin-6 (blood), Interleukin-6 (immunology), Interleukin-8 (blood), Interleukin-8 (immunology), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (immunology), Respiratory Distress Syndrome (blood), Respiratory Distress Syndrome (immunology), Sepsis (blood), Sepsis (immunology), Severity of Illness Index (MeSH), Tumor Necrosis Factor-alpha (blood), Tumor Necrosis Factor-alpha (immunology).
- MESH :
- chemical , blood : Cytokines, Interleukin 1 Receptor Antagonist Protein, Interleukin-18, Interleukin-1beta, Interleukin-6, Interleukin-8, Tumor Necrosis Factor-alpha.
- blood : Coronavirus Infections, Cytokine Release Syndrome, Pneumonia, Viral, Respiratory Distress Syndrome, Sepsis.
- immunology : Coronavirus Infections, Cytokine Release Syndrome, Cytokines, Interleukin 1 Receptor Antagonist Protein, Interleukin-18, Interleukin-1beta, Interleukin-6, Interleukin-8, Pneumonia, Viral, Respiratory Distress Syndrome, Sepsis, Tumor Necrosis Factor-alpha.
- Adult, Aged, COVID-19, Case-Control Studies, Female, Humans, Male, Middle Aged, Pandemics, Severity of Illness Index.
Abstract
BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels compare with those observed in critically ill patients with acute respiratory distress syndrome (ARDS) or sepsis due to other causes.METHODSWe used a Luminex assay to determine expression of 76 cytokines from plasma of hospitalized COVID-19 patients and banked plasma samples from ARDS and sepsis patients. Our analysis focused on detecting statistical differences in levels of 6 cytokines associated with cytokine storm (IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α) between patients with moderate COVID-19, severe COVID-19, and ARDS or sepsis.RESULTSFifteen hospitalized COVID-19 patients, 9 of whom were critically ill, were compared with critically ill patients with ARDS (n = 12) or sepsis (n = 16). There were no statistically significant differences in baseline levels of IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α between patients with COVID-19 and critically ill controls with ARDS or sepsis.CONCLUSIONLevels of inflammatory cytokines were not higher in severe COVID-19 patients than in moderate COVID-19 or critically ill patients with ARDS or sepsis in this small cohort. Broad use of immunosuppressive therapies in ARDS has failed in numerous Phase 3 studies; use of these therapies in unselected patients with COVID-19 may be unwarranted.FUNDINGFunding was received from NHLBI K23 HL125663 (AJR); The Bill and Melinda Gates Foundation OPP1113682 (AJR and CAB); Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases #1016687 NIH/NIAID U19AI057229-16; Stanford Maternal Child Health Research Institute; and Chan Zuckerberg Biohub (CAB).
DOI: 10.1172/jci.insight.140289
PubMed: 32706339
PubMed Central: PMC7526438
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.</title><author><name sortKey="Wilson, Jennifer G" sort="Wilson, Jennifer G" uniqKey="Wilson J" first="Jennifer G" last="Wilson">Jennifer G. Wilson</name><affiliation><nlm:affiliation>Department of Emergency Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Department of Emergency Medicine and.</wicri:noCountry><wicri:noCountry code="no comma">Department of Emergency Medicine and.</wicri:noCountry></affiliation></author><author><name sortKey="Simpson, Laura J" sort="Simpson, Laura J" uniqKey="Simpson L" first="Laura J" last="Simpson">Laura J. Simpson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ferreira, Anne Maud" sort="Ferreira, Anne Maud" uniqKey="Ferreira A" first="Anne-Maud" last="Ferreira">Anne-Maud Ferreira</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Stanford University, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Statistics, Stanford University, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Roque, Jonasel" sort="Roque, Jonasel" uniqKey="Roque J" first="Jonasel" last="Roque">Jonasel Roque</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Asuni, Adijat" sort="Asuni, Adijat" uniqKey="Asuni A" first="Adijat" last="Asuni">Adijat Asuni</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ranganath, Thanmayi" sort="Ranganath, Thanmayi" uniqKey="Ranganath T" first="Thanmayi" last="Ranganath">Thanmayi Ranganath</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Grant, Philip M" sort="Grant, Philip M" uniqKey="Grant P" first="Philip M" last="Grant">Philip M. Grant</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Subramanian, Aruna" sort="Subramanian, Aruna" uniqKey="Subramanian A" first="Aruna" last="Subramanian">Aruna Subramanian</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rosenberg Hasson, Yael" sort="Rosenberg Hasson, Yael" uniqKey="Rosenberg Hasson Y" first="Yael" last="Rosenberg-Hasson">Yael Rosenberg-Hasson</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Maecker, Holden T" sort="Maecker, Holden T" uniqKey="Maecker H" first="Holden T" last="Maecker">Holden T. Maecker</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Holmes, Susan P" sort="Holmes, Susan P" uniqKey="Holmes S" first="Susan P" last="Holmes">Susan P. Holmes</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Stanford University, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Statistics, Stanford University, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Levitt, Joseph E" sort="Levitt, Joseph E" uniqKey="Levitt J" first="Joseph E" last="Levitt">Joseph E. Levitt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rogers, Angela J" sort="Rogers, Angela J" uniqKey="Rogers A" first="Angela J" last="Rogers">Angela J. Rogers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32706339</idno><idno type="pmid">32706339</idno><idno type="doi">10.1172/jci.insight.140289</idno><idno type="pmc">PMC7526438</idno><idno type="wicri:Area/Main/Corpus">000478</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000478</idno><idno type="wicri:Area/Main/Curation">000478</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000478</idno><idno type="wicri:Area/Main/Exploration">000478</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.</title><author><name sortKey="Wilson, Jennifer G" sort="Wilson, Jennifer G" uniqKey="Wilson J" first="Jennifer G" last="Wilson">Jennifer G. Wilson</name><affiliation><nlm:affiliation>Department of Emergency Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Department of Emergency Medicine and.</wicri:noCountry><wicri:noCountry code="no comma">Department of Emergency Medicine and.</wicri:noCountry></affiliation></author><author><name sortKey="Simpson, Laura J" sort="Simpson, Laura J" uniqKey="Simpson L" first="Laura J" last="Simpson">Laura J. Simpson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ferreira, Anne Maud" sort="Ferreira, Anne Maud" uniqKey="Ferreira A" first="Anne-Maud" last="Ferreira">Anne-Maud Ferreira</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Stanford University, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Statistics, Stanford University, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Roque, Jonasel" sort="Roque, Jonasel" uniqKey="Roque J" first="Jonasel" last="Roque">Jonasel Roque</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Asuni, Adijat" sort="Asuni, Adijat" uniqKey="Asuni A" first="Adijat" last="Asuni">Adijat Asuni</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ranganath, Thanmayi" sort="Ranganath, Thanmayi" uniqKey="Ranganath T" first="Thanmayi" last="Ranganath">Thanmayi Ranganath</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Grant, Philip M" sort="Grant, Philip M" uniqKey="Grant P" first="Philip M" last="Grant">Philip M. Grant</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Subramanian, Aruna" sort="Subramanian, Aruna" uniqKey="Subramanian A" first="Aruna" last="Subramanian">Aruna Subramanian</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rosenberg Hasson, Yael" sort="Rosenberg Hasson, Yael" uniqKey="Rosenberg Hasson Y" first="Yael" last="Rosenberg-Hasson">Yael Rosenberg-Hasson</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Maecker, Holden T" sort="Maecker, Holden T" uniqKey="Maecker H" first="Holden T" last="Maecker">Holden T. Maecker</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Holmes, Susan P" sort="Holmes, Susan P" uniqKey="Holmes S" first="Susan P" last="Holmes">Susan P. Holmes</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Stanford University, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Statistics, Stanford University, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Levitt, Joseph E" sort="Levitt, Joseph E" uniqKey="Levitt J" first="Joseph E" last="Levitt">Joseph E. Levitt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rogers, Angela J" sort="Rogers, Angela J" uniqKey="Rogers A" first="Angela J" last="Rogers">Angela J. Rogers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">JCI insight</title><idno type="eISSN">2379-3708</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>COVID-19 (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (immunology)</term><term>Cytokine Release Syndrome (blood)</term><term>Cytokine Release Syndrome (immunology)</term><term>Cytokines (blood)</term><term>Cytokines (immunology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Interleukin 1 Receptor Antagonist Protein (blood)</term><term>Interleukin 1 Receptor Antagonist Protein (immunology)</term><term>Interleukin-18 (blood)</term><term>Interleukin-18 (immunology)</term><term>Interleukin-1beta (blood)</term><term>Interleukin-1beta (immunology)</term><term>Interleukin-6 (blood)</term><term>Interleukin-6 (immunology)</term><term>Interleukin-8 (blood)</term><term>Interleukin-8 (immunology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (immunology)</term><term>Respiratory Distress Syndrome (blood)</term><term>Respiratory Distress Syndrome (immunology)</term><term>Sepsis (blood)</term><term>Sepsis (immunology)</term><term>Severity of Illness Index (MeSH)</term><term>Tumor Necrosis Factor-alpha (blood)</term><term>Tumor Necrosis Factor-alpha (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antagoniste du récepteur à l'interleukine-1 (immunologie)</term><term>Antagoniste du récepteur à l'interleukine-1 (sang)</term><term>Cytokines (immunologie)</term><term>Cytokines (sang)</term><term>Facteur de nécrose tumorale alpha (immunologie)</term><term>Facteur de nécrose tumorale alpha (sang)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (sang)</term><term>Interleukine-1 bêta (immunologie)</term><term>Interleukine-1 bêta (sang)</term><term>Interleukine-18 (immunologie)</term><term>Interleukine-18 (sang)</term><term>Interleukine-6 (immunologie)</term><term>Interleukine-6 (sang)</term><term>Interleukine-8 (immunologie)</term><term>Interleukine-8 (sang)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (immunologie)</term><term>Pneumopathie virale (sang)</term><term>Sepsie (immunologie)</term><term>Sepsie (sang)</term><term>Sujet âgé (MeSH)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term><term>Interleukin 1 Receptor Antagonist Protein</term><term>Interleukin-18</term><term>Interleukin-1beta</term><term>Interleukin-6</term><term>Interleukin-8</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Cytokine Release Syndrome</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome</term><term>Sepsis</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antagoniste du récepteur à l'interleukine-1</term><term>Cytokines</term><term>Facteur de nécrose tumorale alpha</term><term>Infections à coronavirus</term><term>Interleukine-1 bêta</term><term>Interleukine-18</term><term>Interleukine-6</term><term>Interleukine-8</term><term>Pneumopathie virale</term><term>Sepsie</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Cytokine Release Syndrome</term><term>Cytokines</term><term>Interleukin 1 Receptor Antagonist Protein</term><term>Interleukin-18</term><term>Interleukin-1beta</term><term>Interleukin-6</term><term>Interleukin-8</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome</term><term>Sepsis</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antagoniste du récepteur à l'interleukine-1</term><term>Cytokines</term><term>Facteur de nécrose tumorale alpha</term><term>Infections à coronavirus</term><term>Interleukine-1 bêta</term><term>Interleukine-18</term><term>Interleukine-6</term><term>Interleukine-8</term><term>Pneumopathie virale</term><term>Sepsie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>COVID-19</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Indice de gravité de la maladie</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels compare with those observed in critically ill patients with acute respiratory distress syndrome (ARDS) or sepsis due to other causes.METHODSWe used a Luminex assay to determine expression of 76 cytokines from plasma of hospitalized COVID-19 patients and banked plasma samples from ARDS and sepsis patients. Our analysis focused on detecting statistical differences in levels of 6 cytokines associated with cytokine storm (IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α) between patients with moderate COVID-19, severe COVID-19, and ARDS or sepsis.RESULTSFifteen hospitalized COVID-19 patients, 9 of whom were critically ill, were compared with critically ill patients with ARDS (n = 12) or sepsis (n = 16). There were no statistically significant differences in baseline levels of IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α between patients with COVID-19 and critically ill controls with ARDS or sepsis.CONCLUSIONLevels of inflammatory cytokines were not higher in severe COVID-19 patients than in moderate COVID-19 or critically ill patients with ARDS or sepsis in this small cohort. Broad use of immunosuppressive therapies in ARDS has failed in numerous Phase 3 studies; use of these therapies in unselected patients with COVID-19 may be unwarranted.FUNDINGFunding was received from NHLBI K23 HL125663 (AJR); The Bill and Melinda Gates Foundation OPP1113682 (AJR and CAB); Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases #1016687 NIH/NIAID U19AI057229-16; Stanford Maternal Child Health Research Institute; and Chan Zuckerberg Biohub (CAB).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32706339</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2379-3708</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>17</Issue><PubDate><Year>2020</Year><Month>09</Month><Day>03</Day></PubDate></JournalIssue><Title>JCI insight</Title><ISOAbbreviation>JCI Insight</ISOAbbreviation></Journal><ArticleTitle>Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1172/jci.insight.140289</ELocationID><ELocationID EIdType="pii" ValidYN="Y">140289</ELocationID><Abstract><AbstractText>BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels compare with those observed in critically ill patients with acute respiratory distress syndrome (ARDS) or sepsis due to other causes.METHODSWe used a Luminex assay to determine expression of 76 cytokines from plasma of hospitalized COVID-19 patients and banked plasma samples from ARDS and sepsis patients. Our analysis focused on detecting statistical differences in levels of 6 cytokines associated with cytokine storm (IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α) between patients with moderate COVID-19, severe COVID-19, and ARDS or sepsis.RESULTSFifteen hospitalized COVID-19 patients, 9 of whom were critically ill, were compared with critically ill patients with ARDS (n = 12) or sepsis (n = 16). There were no statistically significant differences in baseline levels of IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α between patients with COVID-19 and critically ill controls with ARDS or sepsis.CONCLUSIONLevels of inflammatory cytokines were not higher in severe COVID-19 patients than in moderate COVID-19 or critically ill patients with ARDS or sepsis in this small cohort. Broad use of immunosuppressive therapies in ARDS has failed in numerous Phase 3 studies; use of these therapies in unselected patients with COVID-19 may be unwarranted.FUNDINGFunding was received from NHLBI K23 HL125663 (AJR); The Bill and Melinda Gates Foundation OPP1113682 (AJR and CAB); Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases #1016687 NIH/NIAID U19AI057229-16; Stanford Maternal Child Health Research Institute; and Chan Zuckerberg Biohub (CAB).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>Jennifer G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Laura J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferreira</LastName><ForeName>Anne-Maud</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Statistics, Stanford University, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rustagi</LastName><ForeName>Arjun</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roque</LastName><ForeName>Jonasel</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asuni</LastName><ForeName>Adijat</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranganath</LastName><ForeName>Thanmayi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grant</LastName><ForeName>Philip M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Subramanian</LastName><ForeName>Aruna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosenberg-Hasson</LastName><ForeName>Yael</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maecker</LastName><ForeName>Holden T</ForeName><Initials>HT</Initials><AffiliationInfo><Affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holmes</LastName><ForeName>Susan P</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>Department of Statistics, Stanford University, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levitt</LastName><ForeName>Joseph E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blish</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rogers</LastName><ForeName>Angela J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K23 HL125663</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 AI007502</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AI057229</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JCI Insight</MedlineTA><NlmUniqueID>101676073</NlmUniqueID><ISSNLinking>2379-3708</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508606">CXCL8 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508585">IL1B protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C507763">IL1RN protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053590">Interleukin 1 Receptor Antagonist Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020382">Interleukin-18</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016209">Interleukin-8</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C439524">TNF protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000080424" MajorTopicYN="N">Cytokine Release Syndrome</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053590" MajorTopicYN="N">Interleukin 1 Receptor Antagonist Protein</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020382" MajorTopicYN="N">Interleukin-18</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016209" MajorTopicYN="N">Interleukin-8</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018805" MajorTopicYN="N">Sepsis</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Cytokines</Keyword><Keyword MajorTopicYN="Y">Inflammation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32706339</ArticleId><ArticleId IdType="pii">140289</ArticleId><ArticleId IdType="doi">10.1172/jci.insight.140289</ArticleId><ArticleId IdType="pmc">PMC7526438</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Clin Invest. 2020 May 1;130(5):2620-2629</Citation><ArticleIdList><ArticleId IdType="pubmed">32217835</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2002 Dec 7;360(9348):1831-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12480361</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2019 Dec;47(12):1680-1691</Citation><ArticleIdList><ArticleId IdType="pubmed">31567349</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 1995 Apr;107(4):1062-73</Citation><ArticleIdList><ArticleId IdType="pubmed">7705118</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2020 May;46(5):846-848</Citation><ArticleIdList><ArticleId IdType="pubmed">32125452</ArticleId></ArticleIdList></Reference><Reference><Citation>Semin Immunopathol. 2017 Jul;39(5):529-539</Citation><ArticleIdList><ArticleId IdType="pubmed">28466096</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytokine Growth Factor Rev. 2020 Jun;53:25-32</Citation><ArticleIdList><ArticleId IdType="pubmed">32446778</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 28;395(10229):1054-1062</Citation><ArticleIdList><ArticleId IdType="pubmed">32171076</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2018 Sep;6(9):691-698</Citation><ArticleIdList><ArticleId IdType="pubmed">30078618</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2018 Nov;44(11):1859-1869</Citation><ArticleIdList><ArticleId IdType="pubmed">30291376</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2020 Mar 4;11(1):1177</Citation><ArticleIdList><ArticleId IdType="pubmed">32132525</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2020 Jun 15;204(12):3425-3433</Citation><ArticleIdList><ArticleId IdType="pubmed">32376648</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation><ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Apr 4;395(10230):1111</Citation><ArticleIdList><ArticleId IdType="pubmed">32220278</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2016 May 31;6:26996</Citation><ArticleIdList><ArticleId IdType="pubmed">27243383</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Stanford (Californie)</li></settlement><orgName><li>Université Stanford</li></orgName></list><tree><noCountry><name sortKey="Wilson, Jennifer G" sort="Wilson, Jennifer G" uniqKey="Wilson J" first="Jennifer G" last="Wilson">Jennifer G. Wilson</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Simpson, Laura J" sort="Simpson, Laura J" uniqKey="Simpson L" first="Laura J" last="Simpson">Laura J. Simpson</name></region><name sortKey="Asuni, Adijat" sort="Asuni, Adijat" uniqKey="Asuni A" first="Adijat" last="Asuni">Adijat Asuni</name><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><name sortKey="Ferreira, Anne Maud" sort="Ferreira, Anne Maud" uniqKey="Ferreira A" first="Anne-Maud" last="Ferreira">Anne-Maud Ferreira</name><name sortKey="Grant, Philip M" sort="Grant, Philip M" uniqKey="Grant P" first="Philip M" last="Grant">Philip M. Grant</name><name sortKey="Holmes, Susan P" sort="Holmes, Susan P" uniqKey="Holmes S" first="Susan P" last="Holmes">Susan P. Holmes</name><name sortKey="Levitt, Joseph E" sort="Levitt, Joseph E" uniqKey="Levitt J" first="Joseph E" last="Levitt">Joseph E. Levitt</name><name sortKey="Maecker, Holden T" sort="Maecker, Holden T" uniqKey="Maecker H" first="Holden T" last="Maecker">Holden T. Maecker</name><name sortKey="Ranganath, Thanmayi" sort="Ranganath, Thanmayi" uniqKey="Ranganath T" first="Thanmayi" last="Ranganath">Thanmayi Ranganath</name><name sortKey="Rogers, Angela J" sort="Rogers, Angela J" uniqKey="Rogers A" first="Angela J" last="Rogers">Angela J. Rogers</name><name sortKey="Roque, Jonasel" sort="Roque, Jonasel" uniqKey="Roque J" first="Jonasel" last="Roque">Jonasel Roque</name><name sortKey="Rosenberg Hasson, Yael" sort="Rosenberg Hasson, Yael" uniqKey="Rosenberg Hasson Y" first="Yael" last="Rosenberg-Hasson">Yael Rosenberg-Hasson</name><name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name><name sortKey="Subramanian, Aruna" sort="Subramanian, Aruna" uniqKey="Subramanian A" first="Aruna" last="Subramanian">Aruna Subramanian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidStanfordV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000646 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000646 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidStanfordV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32706339
|texte= Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32706339" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidStanfordV1
| This area was generated with Dilib version V0.6.38. |  |